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Yes, that looks like a condition called Gular Edema. It is excess fluid in the tissues. It is not deadly and no one really knows why some chameleons get it. Speculation is over supplementation, but that is really a guess. I dealt with it with a chameleon that I took in from another member. He lived to over 6 yrs old. He ate and drank fine, and it would come and go in severity. The previous owner never really gave him much in the way of supplements, so that kinda shot down the theory of over supplementation for me . Sometimes pregnant females will get it and after they lay eggs it will go away. I wouldn't worry about it too much, other than it may not look cosmetically pretty.
Just randomly noticed this weird "turkey gobbler" on my chameleons throat. Wasn't there before a few days ago. Any ideas what this is?