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You can get away with housing 2 female panthers together until one bites the other.....LOL
I find that if you provide adequate basking heat and plenty of food, you will lessen the chances of an incident. I have had odd occasions where 2 females will fight at very young ages ( as early as 8 weeks old), but that is rare.
I would suggest , that with food and basking heat not being a source of friction, the next factor would be competition for a mate, either real or perceived. In other words, they may start to stake a claim to available breeding opportunity once they are sexually mature. That can start around the 5 - 8 month mark.
Best to separate them as soon as possible, but definitely split them up by 4 - 6 months of age.