Follow along with the video below to see how to install our site as a web app on your home screen.
Note: This feature may not be available in some browsers.
You know all of those factors for all the ingredients in your vitamin specifically for reptilian mucosa and physiology? Yes, reptilian physiology and pharmacokinetics can be that different.http://www.ijppsjournal.com/Vol3Suppl2/1092.pdf
Factors affecting the sublingual absorption
Lipophilicity of drug: For a drug to be absorbed completely through sublingual route, the drug must have slightly higher lipid solubility than that required for GI absorption is necessary for passive permeation.
Solubility in salivary secretion: In addition to high lipid solubility, the drug should be soluble in aqueous buccal fluids i.e. biphasic solubility of drug is necessary for absorption.
pH and pKa of the saliva: As the mean pH of the saliva is 6.0, this pH favors the absorption of drugs which remain unionized. Also, the absorption of the drugs through the oral mucosa occurs if the pKa is greater than 2 for an acid and less than 10 for a base.
Binding to oral mucosa: Systemic availability of drugs that bind to oral mucosa is poor.
Thickness of oral epithelium: As the thickness of sublingual epithelium is 100‐200 μm which is less as compared to buccal thickness. So the absorption of drugs is faster due to thinner epithelium and also the immersion of drug in smaller volume of saliva.
Oil-to-water partition coefficient: Compounds with favorable oil‐ to‐water partition coefficients are readily absorbed through the oral mucosa. An oil‐water partition coefficient range of 40‐2000 is considered optimal for the drugs to be absorbed sublingually.
....with a liquid or syrup you can ensure how much intake your chameleon is getting by dropping a recommended dose instead of guessing on how many crickets he/she may eat.
justin
could not have said it better lolThis thread is ripe with weird statements, to put it nicely...