It looks like dehydration to me. i found this info at
http://chamworld.blogspot.com/2008/0...hydration.html on symptons.
Dehydration is the most common death of chameleons in captivity. It is extremely fatal if not treated as soon as possible. Dehydration is pretty much a self-explanatory condition mostly caused by inability in giving your chameleon enough water, delivering a proper drinking method, and maintaining humidity. However, if your husbandry, misting, and watering method are proper and your chameleon is STILL dehydrated, there might be an even more serious underlying problem. If that is the case, you will need to consult your veterinarian to find out exactly what is wrong. An untreated dehydration can permanently damage your chameleon's kidney and liver which lead to fatality. A chameleon owner has to be alert if his/her chameleon start to show the symptoms of dehydration. A Chameleon in this condition can go spiraling down hill in no time. Please refer to the chameleon care chapter for proper enclosure, misting, and drinking method
Symptoms to watch out for:
Sunken eyes (Be aware, the chameleon in the case study is already in advanced stage of dehydration. When your chameleon exhibits the same symptom in the picture, you need a vet to treat and hydrate your chameleon).
A yellow or orange urate
Loss of appetite and chameleon appeared lethargic
When pulled GENTLY with 2 fingers, the skin is too slow to return back to its position (or, even worse, does not go back at all).