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I get red marks on my skin when my cham climbs on my arm. However, that's what I signed up for when I got my cham. Chameleons need these claws in order to climb- they do not have the same foots structure of geckos.
No claws/clipped claws = hard time climbing screened surfaces or gripping on branches. Considering how chams live in trees and branches all their lives, doing anything to their claws is unthinkable.
It's like when people declaw cats-if you can't handle the claws, don't get a cat.
Not trying to be harsh, just a pet peeve of mine.
Get used to it or wear gloves, it's that simple. If you do handle your cham gloveless, make sure to wash the area he climbed (your arm, hand, etc) with soap and water. It's always a good idea to disinfect your arm after handling, especially if your cham gets a good run up your arm and digs in.