I "handled" Spike ONCE since I've gotten him home. That was when I opened the lid of the tupperware he was in while being shipped, and he sprang out like a bat out of hell. Never saw a chameleon move so fast lol! He ran onto my hand and I could tell he was quickly gonna jump off my hand, so I just kept putting each hand in front of the other letting him continue to walk on my hands until I got him to his enclosure.
That was it. Hasn't been handled since then.
I've hand fed him twice (1 bug each time. He wouldn't do any more). Usually he rejects bugs on my hand.
I've tried twice to put my hand near him to see if he would cooperate. Both times he got pretty defensive/aggressive and retreated if I didn't pull my hand away.
I think this is a case by case basis, but I would be real slow and gradual with this personally. Unless your chameleon seems 'receptive' to your hand regularly. Remember, he is probably still even getting used to his new home! So you trying to handle him could also be extra stressful for him, for now. I personally waited until I felt Spike was pretty comfortable in his enclosure before I even tried to hand feed.
Even now, about almost a month and a half of having him home, he is still even getting used to his enclosure IMO.
He seems totally fine with me hanging out near his enclosure and checking him out. He even seems okay with me setting up his bugs while he is basking, inches away. Work in progress!