I can see the image/video. Does your female do this even when you are not around?
For the medication, is it oral or subcutaneous? How do you do this?
To me, it looks like she could have a respiratory infection. Or potentially some liquids in her lungs. But if she does this only when she is feeding, then she might just be irritated with you and may fear that you may medicate her again. Do she keep her mouth open all the time, or just sometimes?
Your humidity levels are quite high, especially for the day. How many times do you mist? I see that you use a dripper because it's
the absolute only way i can get her to drink unless i spray it into her mouth, and i spray a fake plant in her enclosure a little bit every day.
How do know she wasn't drinking any other way? Most of the time, you are not going to see a chameleon drink. I mist my cage, using an automatic mister. But even when I'm standing in front of the cage watching, I never see my jackson's chameleon drink--ever. But I monitor how his eyes look--not sunken in. And I also look at his urates to see if he's well hydrated.
Spraying your chameleon in the face to get her to drink is not a good idea IMO. It triggers her to drink even if she doesn't need to drink. They are designed evolutionarily to drink water any chance they get, perhaps because it doesn't rain every day and they need to take advantage of it, or when they wake up with dew on their face, they lick it up and that's all they need. Having the dripper is perfectly fine, just make sure that it isn't a firehose. It should be a slow drip. This allows them to get air everyone in a while if they need to.
Supplements - Ive only used D3 once with her, and calcium without D3 once every week or two. Ive used vitamins once with her, and the vet gave her a vitamen shot.
Supplementation-wise, you need to be supplementing with calcium without D3 every time you feed her. And D3+multivitamin should be given once or twice a month.
I gut load them with carrots and sweet potatos
You should also feed your insects a variety of leafy greens. Providing a grain of some sort will also help. If you want an easy method, purchase a commercial gutload such as Repashy Bug Burger. It allows you to cook small amounts so nothing spoils. And once cooked, it can be refrigerated for a couple weeks. It has everything in it that you need to gutload. As a college student, I find commercial gutloads such as bug burger to be a huge time saver. It makes feeding insects super easy.
Fecal Description - Last time she peed it only had a little brown, but her hydration has dropped
Could you clarify what you mean by this? Her hydration has dropped? The brown part of the poop has to do with the physical matter/remains of insect feeder while the white/orange part has to do with hydration/water.
Lighting - T5 HO 5.0 on from 8am-9pm
How far away is your T5 HO 5.0 from a branch underneath it? If it's a brand new light, the basking branch can be approximately 8 inches underneath it.
You should ditch the fake plants and go for real plants. It will help your cham feel more secure and less stressed. Since your humidity is so high, you can probably get away with a mix of both fake and live plants. You can also look into plants that dehumidify. There's a bunch of lists out there. These plants may help you reduce the humidity a bit as well.
I haven't seen a picture of your cage, but almost everyone can benefit from adding more branches to their enclosure. Ideally, your chameleon can also get out of sight from any passerby. This is where the live, bushy plants come in. You want a network of branches that lead to and away from these hiding places. You want some branches to be out perfectly in the open and you want others to be partially hidden. A chameleon with less stress has a stronger immune system. This is why we try to recreate the temperature and humidity from where they originate. The closer we get to these parameters, the better off our chameleons will be.